Clinical Trial

Intrapatient Comparison of STN and GPi tTIS in PD

Enrolling by Invitation
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Summary
The goal of this clinical trial is to investigate the therapeutic efficacy of tTIS in patients with Parkinson's disease and to evaluate the immediate effects and conduct intrapatient comparisons of individualized 130 Hz Subthalamic Nucleus-transcranial Temporal Interference Stimulation (STN-tTIS) and Globus Pallidus Internus-transcranial Temporal Interference Stimulation (GPi-tTIS) on motor symptoms in patients with early to mid-stage Parkinson's Disease (PD) during "off" medication states. The main questions this study aims to answer are: 1. Can tTIS significantly improve the motor symptoms of patients with Parkinson's disease? 2. Is the therapeutic effect of STN-tTIS superior to that of GPi-tTIS?
Protocol Amendment History 3 changes
notable Enrollment increased: 30 -> 100 participants 2026-04-23
notable Primary completion pushed: 2026-02-28 -> 2026-11-01 2026-04-23
minor Completion pushed: 2026-03-15 -> 2026-11-01 2026-04-23
Trial Details
NCT Number NCT07018388
Lead Sponsor Ruijin Hospital
Conditions Parkinson Disease
Enrollment 100 participants
Start Date 2025-04-23
Primary Completion 2026-11-01 (estimated)
Study Completion 2026-11-01 (estimated)
Updated on ClinicalTrials.gov 2026-04-22