Clinical Trial

Effects of Cannabidiol on Stress and Nicotine Withdrawal

Study acronym: CREWS
Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users. The main objectives of the study include examining the effect CBD has on stress, tobacco dependence, tobacco withdrawal, and sex differences between these types of stress. Participants will be administered CBD and exposed to stress. Biological and subjective measures will be collected. Participants may be asked to stop use for 24 hours. Researchers will also investigate withdrawal effects between participants who have not smoked nicotine in 24 hours and those who have continued to smoke before each session.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-05-23; most recent amendment 2025-08-25.
Status change: Not Yet Recruiting → Recruiting 2025-08-25
Trial Details
NCT Number NCT07001930
Lead Sponsor Johns Hopkins University
Collaborators: National Institute on Drug Abuse (NIDA), University of Minnesota
Conditions CBD, Stress, Nicotine Dependence, Tobacco Smoking
Enrollment 90 participants
Start Date 2025-08-25
Primary Completion 2029-09-01 (estimated)
Study Completion 2029-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-08-10