Clinical Trial

Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study

Study acronym: KATALYST-AV
Recruiting Phase 2/3
View on ClinicalTrials.gov →
Summary
The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.
Protocol Amendment History 2 changes
notable Trial sites expanded: 70 -> 74 locations 2026-07-07
notable Trial sites expanded: 58 -> 70 locations 2026-04-14
Trial Details
NCT Number NCT07001800
Lead Sponsor Kardigan, Inc.
Conditions Moderate Aortic Valve Stenosis
Enrollment 1,276 participants
Start Date 2025-06-27
Primary Completion 2028-08-31 (estimated)
Study Completion 2030-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-07-06