Treating Traumatic Brain Injury With Transcranial Direct Current Stimulation

Traumatic Brain Injury (TBI) often results in a wide array of cognitive impairments, which can significantly diminish quality of life for affected individuals. While traditional rehabilitation methods typically adopt a standardized approach, it's crucial to acknowledge the significant heterogeneity within the TBI patient population. Neglecting these variations reduces the likelihood of otherwise effective treatments being considered for widespread adoption. Emerging evidence highlights the potential of transcranial direct current stimulation (tDCS) as a promising adjunctive therapy. tDCS, a noninvasive and safe neuro-rehabilitative procedure, has shown efficacy when integrated with cognitive training across various neurological disorders, such as depression, post-stroke aphasia, and neurodegenerative conditions. This study aims to investigate the effectiveness of tDCS paired with behavioral therapy, particularly cognitive training, in improving cognition and executive function in chronic TBI patients. Additionally, tDCs targets in the current study will be tailored to each individual patient, recognizing the patient's unique needs and circumstances

NCT Number	NCT06989970
Lead Sponsor	Johns Hopkins University Collaborators: Ybrain Inc.
Conditions	Traumatic Brain Injury
Enrollment	20 participants
Start Date	2026-09-15
Primary Completion	2029-10-15 (estimated)
Study Completion	2029-10-15 (estimated)
Updated on ClinicalTrials.gov	2026-08-06