Clinical Trial

MEP Up-conditioning to Target Corticospinal Plasticity

Study acronym: uMEP2
Recruiting Early Phase 1
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Summary
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand. Also, brain and spine magnetic resonance imaging will be collected before and after the training. The imaging measurements will tell investigators about how spinal damage, brain function, and brain structure relate to motor presentation and the response to the training.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-05-19; most recent amendment 2026-03-25.
Status change: Not Yet Recruiting → Recruiting 2025-05-27
Trial Details
NCT Number NCT06989905
Lead Sponsor Medical University of South Carolina
Collaborators: Doscher Neurorehabilitation Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions Spinal Cord Injury, Tetraplegia/Tetraparesis
Enrollment 11 participants
Start Date 2025-05-27
Primary Completion 2027-03-31 (estimated)
Study Completion 2027-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-03-30