Persistence of Oral DNA Adducts in Smokers and Vapers

This study aims to better understand what damage caused to oral cells from smoking and vaping might be important in the formation of oral cancers. We will compare levels of DNA damage between those asked to stop smoking or vaping to those who continue to smoke or vape and those who never use tobacco or nicotine products. The goal is to identify damage that is found at higher levels or remains in the oral cells longer because they might be more important in causing cancer than other types of damage.

NCT Number	NCT06983392
Lead Sponsor	University of Minnesota
Conditions	Smokers, Vaping, Healthy Volunteers
Start Date	2026-03-01
Primary Completion	2029-07-30 (estimated)
Study Completion	2030-07-30 (estimated)
Updated on ClinicalTrials.gov	2026-02-13