GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward

The rapid emergence of new and highly effective obesity medications has turned the field of pediatric weight management on its head. Adolescents living with obesity, their caregivers, healthcare providers, healthcare systems, policymakers, and payors are now wondering what role health behavior and lifestyle treatment (HBLT) has in terms of body mass index (BMI) reduction, improvements in quality of life and cardiometabolic health, and mitigating nutritional concerns when medications are used. Is intensive HBLT needed or could low intensity HBLT be an equally effective alternative; and if so, for whom? Our proposed project will answer these important questions that arise daily in the clinical setting and will generate critical new insights to guide decision-making for teens with obesity and the stakeholders who care deeply about them.

NCT Number	NCT06977438
Lead Sponsor	University of Minnesota Collaborators: Patient-Centered Outcomes Research Institute, Novo Nordisk A/S
Conditions	Obesity, Childhood
Enrollment	1,020 participants
Start Date	2026-10-01
Primary Completion	2031-01-31 (estimated)
Study Completion	2032-01-31 (estimated)
Updated on ClinicalTrials.gov	2026-06-16