Adverse Adolescent Pathways to Substance Use

Purpose: This 5-year R01 study will elucidate the role of maturational change across adolescence in neural connectivity and physiological stress responses in the relationship between anxiety and adverse pathways to substance use (APSU). Participants: Children (N=200) aged 12-14 with symptoms of anxiety and their legal caregiver will be recruited from clinical and community sources. Procedures: Youth participants will complete several questionnaires and interviews, undergo neuroimaging while performing cognitive tasks, and have their heart rate and skin conductance monitored during a mildly stressful task. Caregivers will complete several questionnaires.

NCT Number	NCT06977178
Lead Sponsor	University of North Carolina, Chapel Hill Collaborators: National Institute on Drug Abuse (NIDA), RTI International
Conditions	Anxiety, Adolescent Development, Substance Use
Enrollment	180 participants
Start Date	2024-02-20
Primary Completion	2029-06-30 (estimated)
Study Completion	2030-06-30 (estimated)
Updated on ClinicalTrials.gov	2025-05-18