Varenicline for Smoking Reduction in Veterans Not Ready To Quit

In order to reduce the prevalence of cigarette smoking among Veterans, it is vital that healthcare providers offer effective tobacco treatment to all Veterans who smoke, including those not ready to make a quit attempt. Smoking treatments currently available to Veterans who are not ready to quit are only weakly effective. This project will generate new knowledge about the effectiveness of a promising varenicline-based intervention designed to increase quit attempts and long-term abstinence in Veterans who are initially not ready to quit. This project has great potential to engage Veterans not ready to quit smoking in treatment that increases quit attempts and quitting success, thereby reducing morbidity and mortality caused by smoking in Veterans.

NCT Number	NCT06966362
Lead Sponsor	VA Office of Research and Development
Conditions	Veterans, Tobacco Use Disorder, Cigarette Smoking, Tobacco Dependence
Enrollment	400 participants
Start Date	2026-08-17
Primary Completion	2030-06-28 (estimated)
Study Completion	2030-06-28 (estimated)
Updated on ClinicalTrials.gov	2026-07-31