Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: * Does VSS arise from spontaneous activity in brain pathways? * Where in the brain does the activity contributing to VSS arise? * How does brain activity contribute to VSS? Participants will: 1. Undergo assessments and questionnaires to understand visual and mental symptoms, cognitive, and sensory function. 2. Make visual judgements based on images presented to them both inside and outside a magnetic resonance imaging (MRI) machine. 3. Undergo scanning of their brain while inside of an MRI machine.

NCT Number	NCT06961864
Lead Sponsor	University of Minnesota Collaborators: National Institutes of Health (NIH), Mayo Clinic, National Eye Institute (NEI)
Conditions	Visual Snow Syndrome, Migraine, Healthy
Enrollment	100 participants
Start Date	2025-04-11
Primary Completion	2030-03-31 (estimated)
Study Completion	2030-03-31 (estimated)
Updated on ClinicalTrials.gov	2026-01-14