Clinical Trial

Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study

Recruiting
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Summary
The objective of this research study is to understand how Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) affects cognitive networks in the brain, potentially leading to cognitive decline in patients with Parkinson's Disease (PD). A total of 55 participants with PD who have undergone DBS surgery will be recruited from MUSC's Clinical DBS Program. Participants will attend two post-DBS visits: a 3-hour visit for consent, demographic, and cognitive assessments, and a 3-hour DBS-MRI visit to evaluate brain network connectivity with stimulation ON and OFF. These findings will help improve patient selection for surgery and optimize the selection of stimulation targets that minimize undesirable cognitive side effects.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-04-28; most recent amendment 2025-10-10.
Status change: Not Yet Recruiting → Recruiting 2025-10-10
Trial Details
NCT Number NCT06960096
Lead Sponsor Medical University of South Carolina
Collaborators: National Institute of Neurological Disorders and Stroke (NINDS)
Conditions Deep Brain Stimulation, Parkinson Disease
Enrollment 55 participants
Start Date 2025-08-21
Primary Completion 2028-04-01 (estimated)
Study Completion 2028-04-01 (estimated)
Updated on ClinicalTrials.gov 2025-10-14