General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound

The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs. Peripheral endobronchial ultrasound (pEBUS) is the most widely used endoscopic technique in the investigation of peripheral pulmonary lesions (PPL). It is performed in relatively equal proportions under conscious sedation and general anesthesia by interventional pulmonologists throughout the world. Users of conscious sedation justify themselves by the fewer resources consumed and the absence of demonstration of a superior diagnostic yield of general anesthesia while users of general anesthesia claim diagnostic yield and comfort for the patient are superior with their approach. Our main objective is to compare the diagnostic yield of pEBUS under general anesthesia to that obtained under conscious sedation.

NCT Number	NCT06950515
Lead Sponsor	Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Conditions	Lung Cancers, Peripheral Pulmonary Nodules
Enrollment	306 participants
Start Date	2025-09-25
Primary Completion	2027-08 (estimated)
Study Completion	2029-08 (estimated)
Updated on ClinicalTrials.gov	2026-03-06