Clinical Trial

Acute Effects of THC in Older Adult

Study acronym: THC-Aging
Recruiting Phase 1
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Summary
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-04-23; most recent amendment 2025-08-14.
Status change: Not Yet Recruiting → Recruiting 2025-06-16
Trial Details
NCT Number NCT06948136
Lead Sponsor Yale University
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Age-related Cognitive Decline
Enrollment 60 participants
Start Date 2025-06-06
Primary Completion 2027-11-01 (estimated)
Study Completion 2027-11-01 (estimated)
Updated on ClinicalTrials.gov 2025-08-18