Clinical Trial

Exploratory Clinical Study of Claudin18.2-Targeted CAR-DC and CAR-T Therapy in Advanced Colorectal Cancer

Recruiting Phase 1
View on ClinicalTrials.gov →
Record status
This record was last updated April 27, 2025 (before its estimated April 2026 completion). Its status may not reflect the trial's current state.
Summary
This is an open-label, single-arm clinical study designed to evaluate the safety and preliminary efficacy of Claudin18.2-targeted CAR-DC combined with CAR-T cell therapy in patients with advanced colorectal cancer.
Protocol Amendment History 1 change
notable Sponsor changed: Second Affiliated Hospital, School of Medicine, Zhejiang University -> Second Affiliated Hospital, Zhejiang University, School of Medicine 2026-08-09
Trial Details
NCT Number NCT06946615
Lead Sponsor Second Affiliated Hospital, School of Medicine, Zhejiang University
Conditions Colorectal Neoplasia
Enrollment 18 participants
Start Date 2025-04-08
Primary Completion 2026-04 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2025-04-27