Clinical Trial

A Study to Investigate the Effects of Zibotentan/Dapagliflozin Combination Compared to Dapagliflozin Alone in Adult Participants With Chronic Kidney Disease and High Proteinuria

Study acronym: ZODIAC
Recruiting Phase 2
View on ClinicalTrials.gov →
Record status
This record was last updated April 17, 2026 (before its estimated July 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
A Study to Investigate the Effects of Zibotentan/Dapagliflozin Combination Compared to Dapagliflozin Alone in Adult Participants with Chronic Kidney Disease and High Proteinuria
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2025-04-17; most recent amendment 2026-04-14.
Status change: Not Yet Recruiting → Recruiting 2025-05-13
Trial Details
NCT Number NCT06942910
Lead Sponsor AstraZeneca
Conditions Chronic Kidney Disease With High Proteinuria
Enrollment 224 participants
Start Date 2025-05-07
Primary Completion 2026-07-31 (estimated)
Study Completion 2026-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-17