Clinical Trial

A Study to Evaluate the Effect of Formulation and Food on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-011)

Completed Phase 1
View on ClinicalTrials.gov →
Summary
This study has 2 parts. Researchers want to learn what happens to calderasib in a healthy person's body over time in both parts. The goals of the study are: * In Part 1, to compare what happens to calderasib in a person's blood when it is taken as 2 different types of oral tablets * In Part 2, to learn what happens to calderasib in a person's blood when it is taken on an empty stomach or after a meal
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2025-04-17; most recent amendment 2026-02-09.
Status change: Active, Not Recruiting → Completed 2025-10-20
Status change: Recruiting → Active, Not Recruiting 2025-06-18
Status change: Not Yet Recruiting → Recruiting 2025-05-16
Trial Details
NCT Number NCT06942741
Lead Sponsor Merck Sharp & Dohme LLC
Conditions Healthy
Enrollment 52 participants
Start Date 2025-05-13
Primary Completion 2025-06-22 (estimated)
Study Completion 2025-08-04 (estimated)
Updated on ClinicalTrials.gov 2026-02-11