Clinical Trial

Chronic Exogenous Ketosis in HFpEF

Enrolling by Invitation Phase 2
View on ClinicalTrials.gov →
Summary
The goal of this clinical research study is to test what effects a ketone drink will have in people with heart failure with preserved ejection fraction (HFpEF), including on exercise and heart function. Patients with HFpEF often have difficulty exercising, and our goal is to understand whether a ketone drink changes much patients can exercise. The study has three visits, including a baseline visit to assess for study eligibility, and two visits (one after 8 weeks of a ketone drink or a placebo drink, and another one after 8 weeks of whichever drink the participant did not receive the first time).
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2025-04-15; most recent amendment 2025-09-16.
Status change: Not Yet Recruiting → Enrolling by Invitation 2025-09-16
Trial Details
NCT Number NCT06937320
Lead Sponsor Duke University
Conditions Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction, Heart Failure, Diastolic
Enrollment 20 participants
Start Date 2025-07-28
Primary Completion 2027-06 (estimated)
Study Completion 2027-06 (estimated)
Updated on ClinicalTrials.gov 2025-09-17