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Organoid Models of Hepatocellular Carcinoma

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 2 months later Aug 31, 2026 → Nov 15, 2026
See other at-risk trials from Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion pushed from Aug 31, 2026 to Nov 15, 2026
    • Eligibility criteria shortened, about 2 words
  2. Study completion date: Aug 31, 2026 to Dec 31, 2026v3
  3. Primary completion date: Sep 1, 2025 to Aug 31, 2026v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
A promising tool to elucidate the molecular characteristics of HCC are patient-derived organoids (PDOs), three-dimensional cultures of cells that self-organise according to tissue-specific patterns and can be used to test the susceptibility of a specific tumour to anticancer agents. In this study, PDOs for HCC will be developed that closely resemble the tumour microenvironment in vivo and mimic the crosstalk of the gut-liver axis to establish a correlation with patient prognosis and test the efficacy of available systemic therapies.
Trial Details
NCT Number NCT06929845
Lead Sponsor Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions
(from sponsor)		 Hepatocellular Carcinoma, Organoids, Gut Microbiota, Tumor Microenvironment, System Disorders, Digestive, Surgery
Related terms Carcinoma, Hepatocellular, Digestive System Diseases
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov