High-Resolution PET-CT Imaging for Surgical Margin Visualization

Imaging will be exploratory and be used intraoperatively. There have been no discovered risks associated with the device to be used in this study, and none are anticipated given the diagnostic and non-invasive, 'ex vivo' nature of device use. Of note, the surgical resection will proceed as per standard of care and will not be affected by the research protocol. Potential Benefit: Imaging intra-operatively will ensure surgeons to identify at risk resection margins. Time Commitment: There are no additional visits that will be asked of you to partake in this study. Drug is FDA approved and Exposure to Radiation is minimal.

NCT Number	NCT06915454
Lead Sponsor	Vanderbilt-Ingram Cancer Center Collaborators: Vanderbilt University Medical Center, XEOS Medical
Conditions	Cancer, Solid Malignant Tumors, SCC - Squamous Cell Carcinoma, HNSCC, HNSCC,Larynx, Pharynx and Oral Cavity
Enrollment	50 participants
Start Date	2025-09-03
Primary Completion	2027-05 (estimated)
Study Completion	2027-07 (estimated)
Updated on ClinicalTrials.gov	2026-05-08