Clinical Trial

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

Recruiting Phase 2
View on ClinicalTrials.gov →
Summary
To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
Protocol Amendment History 2 changes
notable Primary completion moved earlier: 2031-03-01 -> 2030-07-31 2026-07-25
minor Completion moved earlier: 2033-03-01 -> 2031-07-31 2026-07-25
Trial Details
NCT Number NCT06912763
Lead Sponsor M.D. Anderson Cancer Center
Conditions Fibrosis Syndrome, Lymphedema, Head & Neck Cancer, Fibrosis
Enrollment 250 participants
Start Date 2025-08-08
Primary Completion 2030-07-31 (estimated)
Study Completion 2031-07-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-24