PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer

This is a prospective, randomized, open-label, two-arm phase 2 trial that will evaluate whether the use of Pulsed Low-Dose-Rate radiation technique, as compared to standard radiation, is associated with reduced rates of clinically significant esophagitis during and following chemoradiation.

NCT Number	NCT06906887
Lead Sponsor	Medical College of Wisconsin
Conditions	Esophageal Cancer, Oesophageal Cancer, GastroEsophageal Cancer
Enrollment	50 participants
Start Date	2025-06-17
Primary Completion	2030-11-01 (estimated)
Study Completion	2032-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-28