Mindfulness-based Neurofeedback to Reduce Negative Thinking in CHARMS Adolescents

The study will test the hypothesis that mindfulness-based neurofeedback (mbNF) will improve repetitive negative thinking and social and role functioning over sham neurofeedback in adolescents at risk for serious mental illness. To do so, 90 adolescents ages 14-21 with elevated repetitive negative thinking will be enrolled into a double-blind randomized clinical trial of sessions of mindfulness training with either active mindfulness-based neurofeedback or sham neurofeedback and three months of mindfulness practice and follow up.

NCT Number	NCT06901232
Lead Sponsor	Massachusetts General Hospital
Conditions	Repetitive Negative Thinking, Serious Mental Illness Symptoms
Enrollment	90 participants
Start Date	2027-09
Primary Completion	2029-04 (estimated)
Study Completion	2029-04 (estimated)
Updated on ClinicalTrials.gov	2026-02-12