Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations

Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver targeted stimulation to these HFO generating areas to prevent seizures from occurring. If the outcomes of our research in an acute setting become successful, the investigators will execute a clinical trial and run the developed methods with the implantable BIC system in a chronic ambulatory setting.

NCT Number	NCT06898138
Lead Sponsor	Mayo Clinic Collaborators: National Institute of Neurological Disorders and Stroke (NINDS), Baylor College of Medicine, CorTec GmbH
Conditions	Epilepsy
Enrollment	8 participants
Start Date	2026-11-01
Primary Completion	2029-02-15 (estimated)
Study Completion	2029-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-11