Mechanism of Ketogenic Diet-Induced Hypercholesterolemia

Very-low carbohydrate ketogenic diets can dramatically increase blood cholesterol levels, particularly in normal-weight people, for reasons that are not well understood. This study will enroll normal-weight adults, will identify "responders" who develop high cholesterol on a ketogenic diet, and will measure rates of production and removal of certain types of cholesterol-carrying particles called lipoproteins in responders. The results will clarify the mechanism by which a ketogenic diet can cause high cholesterol in certain susceptible people.

NCT Number	NCT06894004
Lead Sponsor	Washington University School of Medicine
Conditions	Hypercholesterolemia and Hyperlipidemia
Enrollment	100 participants
Start Date	2025-02-24
Primary Completion	2030-11-30 (estimated)
Study Completion	2030-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-23