Clinical Trial

MethaLoad Dose-Finding Study

Recruiting Phase 1
View on ClinicalTrials.gov →
Summary
The goal of this study is to develop a loading dose approach to starting methadone to treat opioid use disorder with fentanyl use ("fentanyl OUD", herein). This study is a participant- and assessor- blinded dose-finding study using the Bayesian optimal interval (BOIN) design. Investigators aim to recruit n=24 participants with fentanyl OUD to a research unit for monitored methadone initiation. Participants will be randomized to standard initiation vs. loading dose initiation at one of four doses.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-03-10.
Status change: Not Yet Recruiting → Recruiting 2025-10-09
Trial Details
NCT Number NCT06877858
Lead Sponsor University of Pennsylvania
Conditions Opioid Use Disorder (OUD)
Enrollment 24 participants
Start Date 2025-09-25
Primary Completion 2027-03 (estimated)
Study Completion 2027-07 (estimated)
Updated on ClinicalTrials.gov 2025-10-14