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Pharmacologic Augmentation of TMS for Depression With D-serine

Study acronym: PAT-DS
StatusRecruiting
PhasePhase 1
Started2025-04-01
View on ClinicalTrials.gov ↗

Amendment history

2026-05-13
Study Status, Arms and Interventions v2
Primary completion date2026-02-01→2026-12-26
Completion date2026-04-01→2027-04-01
InterventionsD-serine + TMS (Combination Product), TMS (Device)→D-serine (Drug), Placebo (Other), TMS (Device)
2025-10-29
Not Yet Recruiting→Recruiting Study Identification, Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Study sites0→1
Study titlerevised
Pharmacologic Augmentation of TMS for Depression withWith D-serine
2025-03-09
Original filing
Mclean Hospital
53 trials monitored
See 1 trial at risk
Depression
2,976 trials monitored
See 162 trials at risk
The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions of rTMS will produce greater clinical outcomes than iTBS with placebo and 18-Hz with placebo.
Trial Details
NCT Number NCT06876129
Lead Sponsor Mclean Hospital
Conditions Depression
Enrollment 60 participants
Start Date 2025-04-01
Primary Completion 2026-12-26 (estimated)
Study Completion 2027-04-01 (estimated)
Updated on ClinicalTrials.gov 2026-05-15