Clinical Trial

Pharmacologic Augmentation of TMS for Depression With D-serine

Study acronym: PAT-DS
Recruiting Phase 1
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Summary
The goal of this study is to test whether combining D-serine with 30 treatments of a) iTBS and b) 18-Hz protocols will enhance clinical outcomes compared to rTMS with placebo (i.e., sugar pill). The investigators hypothesize that NMDA receptor activation via D-serine combined with repeated sessions of rTMS will produce greater clinical outcomes than iTBS with placebo and 18-Hz with placebo.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2025-03-09; most recent amendment 2026-05-13.
Status change: Not Yet Recruiting → Recruiting 2025-10-29
Trial Details
NCT Number NCT06876129
Lead Sponsor Mclean Hospital
Conditions Depression
Enrollment 60 participants
Start Date 2025-04-01
Primary Completion 2026-12-26 (estimated)
Study Completion 2027-04-01 (estimated)
Updated on ClinicalTrials.gov 2026-05-15