Remote Approaches for Optimizing Weight Loss (Elevate Weight Loss Trial)

The purpose of this trial is to compare two delivery formats for weight loss (automated online program vs. group-based videoconference program) and to examine the added effect of individual coaching (vs. no coaching) for individuals with overweight or obesity. All participants enrolled in this study will receive a 12-month behavioral weight loss program (varying in delivery format and individual support), and will be provided with weight loss, calorie intake, and exercise goals. Assessments will occur at baseline, 6 (mid-treatment), 12 (post-treatment), and 18 months (following 6 months of no intervention). We will also seek to determine which combination of intervention approaches works best for whom and develop algorithms which can be used to refer patients into remote programs in clinical settings or future trials.

NCT Number	NCT06875622
Lead Sponsor	The Miriam Hospital Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Obesity/therapy
Enrollment	490 participants
Start Date	2025-03-03
Primary Completion	2028-04-27 (estimated)
Study Completion	2028-10-31 (estimated)
Updated on ClinicalTrials.gov	2025-03-18