Neuromodulation and fMRI in Neurodegenerative Diseases Study

In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states. Transcranial alternating current stimulation (tACS) has been suggested as a promising, non-invasive, method of normalizing network connectivity and hence improving cognition, notably memory. This study will examine the efficacy of tACS at improving working memory performance in patients with neurodegeneration and its correlation to changes in network connectivity, based on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) imaging data.

NCT Number	NCT06873750
Lead Sponsor	Sunnybrook Health Sciences Centre
Conditions	Mild Cognitive Impairment, Traumatic Brain Injury, Neurodegeneration
Enrollment	30 participants
Start Date	2026-06-01
Primary Completion	2028-09-01 (estimated)
Study Completion	2028-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-01