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IGHID 12334 - After the Flood: Optimal Strategies to Prevent Malaria Epidemics Caused by Severe Flooding

Study acronym: IGHID12334
StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Jul 1, 2026 → Oct 31, 2026
See other at-risk trials from University of North Carolina, Chapel Hill

Record History

  1. Primary and study completion pushed from Jul 1, 2026 to Oct 31, 2026 Eligibility criteria expanded, about 7 words · Secondary endpoints: details revised at 5 of 11 entries · Study description expanded, about 9 words Show 3 more changesShow less
    • Eligibility criteria expanded, about 7 words
    • Secondary endpoints: details revised at 5 of 11 entries
    • Study description expanded, about 9 words
  2. Primary and study completion dates: Mar 2030 to Jul 1, 2026 Trial status: Recruiting to Active, Not Recruiting · Site details revisedv4 Show 2 more changesShow less
    • Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
  3. Re-verified, no change to tracked fieldsv3
  4. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Mar 2025 to Mar 12, 2025 · Site details revisedv2 Show 2 more changesShow less
    • Start date changed from estimate of Mar 2025 to Mar 12, 2025
    • Site details revised
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to test different ways to prevent malaria infections after flooding. To accomplish this, the investigators will assign villages to different control strategies and measure the number of malaria infections in each of the villages. Residents of all villages will receive new bed nets, but in some villages, residents will be provided with a monthly medication Dihydroartemisinin-piperaquine (DP) (a drug that is approved by the World Health Organization (WHO) and regulatory authorities and widely used in Africa for Malaria treatment. This drug is not approved by Food and Drug Administration (FDA) because it is not used in the US,) to prevent malaria, while others will also receive a treatment that can be placed into pools of water around the home to prevent mosquitoes from breeding there. The investigators will monitor the participant and their household members for mosquitoes and malaria over a period of 12 months after the flooding This study is important because, similar approaches could be used to prevent malaria after floods, which is occurring more frequently.
Trial Details
NCT Number NCT06870344
Lead Sponsor University of North Carolina, Chapel Hill
Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), North Carolina State University, Mbarara University of Science and Technology
Conditions Malaria Infection, Malaria Falciparum
Enrollment 36,000 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov