Clinical Trial

Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide

Study acronym: SEIZE-TBI
Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
The purpose of this study is to assess the incidence of early post-traumatic seizures. The study will also assess the benefit of lacosamide compared to levetiracetam in regards to agitation and behavioral adverse effects in patients with traumatic brain injury requiring seizure prophylaxis.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2025-03-04; most recent amendment 2026-04-21.
Status change: Not Yet Recruiting → Recruiting 2025-04-23
Trial Details
NCT Number NCT06866691
Lead Sponsor Wake Forest University Health Sciences
Conditions Traumatic Brain Injury
Enrollment 600 participants
Start Date 2025-04-18
Primary Completion 2027-04 (estimated)
Study Completion 2027-04 (estimated)
Updated on ClinicalTrials.gov 2026-04-24