Clinical Trial

Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency

Study acronym: ENCODE
Not Yet Recruiting
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Record status
This record was last updated January 7, 2026 (before its estimated April 2026 completion). Its status may not reflect the trial's current state.
Summary
The goal of this observational study is to study the effects of treating women with Primary Ovarian Insufficiency (POI) with estrogen replacement therapy to bolster the evidence backing cardiometabolic preventive care in women with POI. The main question it aims to answer is: Does 6 months of estrogen replacement therapy for women with POI improved markers of heart health? Women newly diagnosed with POI (within 6 months) who are planning to start estrogen replacement therapy from their clinical provider will undergo assessment of markers of heart health before and after 6 months of treatment. These markers will also be compared to those obtained from healthy women without POI.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2025-03-04.
Trial Details
NCT Number NCT06866119
Lead Sponsor Massachusetts General Hospital
Conditions Primary Ovarian Insufficiency, Premature Menopause, Metabolic Complications, Endothelial Function (FMD), Estrogen Replacement Therapy
Enrollment 45 participants
Start Date 2026-03-01
Primary Completion 2026-04 (estimated)
Study Completion 2026-06 (estimated)
Updated on ClinicalTrials.gov 2026-01-07