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Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors

StatusRecruiting
PhaseNot applicable
Started2025-06-02
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Mar 2027 → Jul 2027
See other at-risk trials from St. Jude Children's Research Hospital

Amendment history

2026-09-18
Primary completion pushed: 2027-03 → 2027-07
2026-05-14
Study Status, Arms and Interventions, Eligibility v6
Eligibility criteria-10 characters
[...] (lean mass divided by height in meters squared). Survivor - or Control-Participant is able and willing to give informed consent Exc [...]
2026-04-22
Study Status, Contacts/Locations v5
Study sitescontacts updated at 1 of 1 site
2026-03-04
Study Status v4
Primary completion date2026-01→2027-03
2025-11-03
Study Status, Study Design, Eligibility v3
Enrollment target40→60
Eligibility criteria+2 characters
[...] ned by relative lean mass z-score of less than or equal to -10.5 SD (lean mass divided by height in meters squared). Survivo [...]
Show 2 earlier versions
2025-06-02
Study Status v2
Start dateestimated 2025-04→confirmed 2025-06-02
2025-03-12
Study Status v1
Start date2025-02→2025-04
2025-02-04
Original filing
The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow. Primary Objective • To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls. Secondary Objective * To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors. * To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.
Trial Details
NCT Number NCT06819475
Lead Sponsor St. Jude Children's Research Hospital
Conditions Childhood Cancer, Muscle Weakness
Enrollment 60 participants
Start Date 2025-06-02
Primary Completion 2027-07 (estimated)
Study Completion 2028-01 (estimated)
Updated on ClinicalTrials.gov 2026-09-17