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Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke

Study acronym: TNK-FLOW
StatusEnrolling by Invitation
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 1 year 8 months later Sep 2026 → Jun 2028
See other at-risk trials from Wake Forest University Health Sciences

Record History

See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fields
  2. Primary completion pushed from Sep 2026 to Jun 2028
    • Study completion pushed from Dec 2026 to Jun 2028
    • Eligibility criteria expanded, about 23 words
  3. Eligibility criteria expanded, about 13 wordsv11
  4. Re-verified, no change to tracked fieldsv10
  5. Start date changed from estimate of Sep 2025 to Sep 22, 2025v9
Show 7 earlier versionsHide 7 earlier versions
  1. Trial status: Not Yet Recruiting to Enrolling by Invitation
    • Primary completion date: Aug 2026 to Sep 2026
    • Study completion date: Aug 2026 to Dec 2026
    • Site contact updated
    v8
  2. Primary and study completion dates: Jul 2026 to Aug 2026
    • Start date: Aug 2025 to Sep 2025
    v7
  3. Primary and study completion dates: Jun 2026 to Jul 2026
    • Start date: Jul 2025 to Aug 2025
    v6
  4. Start date: Jun 2025 to Jul 2025v5
  5. Re-verified, no change to tracked fieldsv4
  6. Start date: May 2025 to Jun 2025v3
  7. Start date: Mar 2025 to May 2025v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The purpose of this study is to determine the safety and feasibility of using intra-arterial Tenecteplase in patients undergoing blood clot extraction for treatment of acute ischemic (non-bleeding) stroke. Intravenous Tenecteplase is FDA-approved to treat patients with an ischemic stroke presenting within the 0-3-hour time window.
Trial Details
NCT Number NCT06781385
Lead Sponsor Wake Forest University Health Sciences
Collaborators: Genentech, Inc.
Conditions
(from sponsor)		 Acute Ischemic Stroke
Related terms Intracranial Hemorrhages, Ischemic Stroke, Stroke, Thrombosis
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov