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HDAC Inhibitor Combination With Chemoimmunotherapy in the Neoadjuvant Treatment of pMMR Locally Advanced Colon Cancer

StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated November 29, 2024 (before its estimated September 30, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Study First Submitted
The purpose of this clinical trial is to learn the safety and efficacy of HDAC inhibitors in combination with neoadjuvant immunochemotherapy compared to neoadjuvant therapy in the treatment of locally advanced colon cancer. The main questions it aims to answer are: Can HDAC inhibitors combined with neoadjuvant immunochemotherapy improve the rate of pCR and complete resection in patients? Are HDAC inhibitors combined with neoadjuvant immunochemotherapy safe and reliable? Does the combination of HDAC inhibitors and neoadjuvant immunochemotherapy achieve a better long-term prognosis than neoadjuvant therapy?
Trial Details
NCT Number NCT06709885
Lead Sponsor Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Collaborators: Southwest Hospital, China, Xinqiao Hospital of Chongqing, First Affiliated Hospital of Chongqing Medical University, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing University Cancer Hospital, Chongqing General Hospital, Chongqing Traditional Chinese Medicine Hospital, Chongqing Shapingba District People's Hospital, Chongqing Seventh People's Hospital, Chongqing Renji Hospital, University of Chinese Academy of Sciences, The 13th People's Hospital of Chongqing
Conditions
(from sponsor)		 Colon Adenocarcinoma
Related terms Colonic Neoplasms
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov