Surgery Alone Verus Sugery Combined with Dose-reduced Radiotherapy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma

The goal of this clinical trial is to compare the efficacy and safety of endoscopic nasopharyngectomy combined with retropharyngeal lymph nodes dissection plus bilateral upper neck lymph node dissection or plus postoperative low-dose radiotherapy in newly diagnosed stage Ⅰ nasopharyngeal carcinoma.

NCT Number	NCT06688760
Lead Sponsor	Ming-Yuan Chen Collaborators: Fifth Affiliated Hospital, Sun Yat-Sen University, Sun Yat-Sen University Cancer Center, Fifth Affiliated Hospital of Guangzhou Medical University, Huazhong University of Science and Technology Union Shenzhen Hospital, Nanfang Hospital, Southern Medical University, First Affiliated Hospital, Sun Yat-Sen University, First People's Hospital of Foshan, Zhongshan People's Hospital, Guangdong, China
Conditions	Nasopharyngeal Carcinoma, Surgery, Radiotherapy
Enrollment	86 participants
Start Date	2023-11-01
Primary Completion	2028-11-01 (estimated)
Study Completion	2028-11-01 (estimated)
Updated on ClinicalTrials.gov	2024-11-14