Testing Pulse Stimulation to Improve Motor Function in People With ALS: A Pilot Study

The goal of this clinical trial is to assess the efficacy of TPS of the motor cortex on biomarkers and clinical endpoints in patients with ALS. The main questions it aims to answer are: * Stage 1: Is there a change in the short intracortical inhibition (SICI) of the motor cortex from baseline to week 8? * Stage 2: Is there a change from baseline to month 6 in the ALS functional rating scale-revised (ALSFRS-R) total score? In stage 2, researchers will compare the group receiving the stimulation vs the group receiving a sham stimulation to see if there is a difference in motor cortex activity and in the ALSFRS-R score Participants will receive either: * the TPS treatment * a sham TPS treatment

NCT Number	NCT06681610
Lead Sponsor	Parc de Salut Mar
Conditions	Amyotrophic Lateral Sclerosis (ALS)
Enrollment	50 participants
Start Date	2024-10-24
Primary Completion	2025-04 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2024-11-08