Clinical Trial

Early Amiodarone in Shockable Cardiac Arrest

Study acronym: Early-Amio
Recruiting Phase 3
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Summary
The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2024-11-06; most recent amendment 2025-12-17.
Status change: Not Yet Recruiting → Recruiting 2024-12-17
Trial Details
NCT Number NCT06680869
Lead Sponsor Oregon Health and Science University
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions Cardiac Arrest
Enrollment 585 participants
Start Date 2025-01-01
Primary Completion 2027-12-31 (estimated)
Study Completion 2028-01-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-19