Characterisation of the Biochemical Profile and Physiology of the Coronary Circulation in Takotsubo Syndrome

Consecutive consenting patients over the age of 18 years diagnosed with Takotsubo syndrome according to the position statement of the European Journal of Heart Failure (2016) will be included in the study. The primary endpoint is to evaluate the incidence of coronary microcirculation dysfunction and its correlation with the clinical presentation and the prognosis in patients with TAKO-Tsubo syndrome. Secondary endpoints will be to assess the incidence of in-hospital mortality, the prevalence of cardiogenic shock, the correlation between the levels of biomarkers analyzed, microvascular dysfunction, perceived quality of life, and angina severity during hospitalization and at subsequent follow-ups, and the influence of knowledge of the level of microvascular dysfunction on clinical management and prescribed therapies. Enrolment: 2 years, follow-up: 1 month and 1 year. Total: 3 years.

NCT Number	NCT06669962
Lead Sponsor	A.O.U. Città della Salute e della Scienza
Conditions	Tako Tsubo Cardiomyopathy
Enrollment	50 participants
Start Date	2024-07-10
Primary Completion	2026-06-27 (estimated)
Study Completion	2027-06-27 (estimated)
Updated on ClinicalTrials.gov	2024-11-01