2026-09-01
notable
Study Status, Arms and Interventions v5
Trial arms changed: 8 → 10
Interventions modified
2026-04-02
minor
Study Identification, Study Status, Study Description, Outcome Measures v4
Secondary endpoints5 to 6 entries
Disease Control Rate (DCR)
Study description-14 characters
This is a prospective, open-label, multicenter, phase II2 platform trial.
The purpose of this study is to test the sa [...]
2026-03-15
minor
Study Status, Study Description, Study Design, Arms and Interventions v3
Enrollment target120→160
Study arms6→8
InterventionsFamitinib (Drug), Fat Module Formula for Special Medical Purposes (Dietary Supplement), SHR-A1811 (Drug), SHR-A1921 (Drug), SHR-A2009…→9MW2821 (Drug), Famitinib (Drug), Fat Module Formula for Special Medical Purposes (Dietary Supplement), SHR-A1811 (Drug), SHR-A1921 (Drug)…
Study description-193 characters
[...] 1921 (TROP2 ADC), SHR-A2009 (HER3 ADC) and SHR-A2102 (Nectin-4 ADC).
This platform trial is adaptive design.
Novel ADC re [...] d target, the subjects were randomly assigned to each cohort by adaptive randomization.
On the basis of previous clinical data at our center, we l [...] ional 10 results according to the Bayesian monitoring method, and the proportion of random assignment to each cohort will be adjusted according to the calculated posterior probability using response-adaptive randomization (RAR).
Graduation (successful validation) or elimination (failed [...]
2025-11-17
minor
Study Status, Oversight, Arms and Interventions, Contacts/Locations v2
Study arms4→6
InterventionsSHR-A1811 (Drug), SHR-A1921 (Drug), SHR-A2009 (Drug), SHR-A2102 (Drug)→Famitinib (Drug), Fat Module Formula for Special Medical Purposes (Dietary Supplement), SHR-A1811 (Drug), SHR-A1921 (Drug), SHR-A2009…
Study sitescontacts updated at 1 of 1 site
2024-12-08
minor
Study Status, Oversight, Contacts/Locations v1
Study sitescontacts updated at 1 of 1 site
2024-10-17
minor
Original filing