Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation

The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological cortical sing of MCI in PD. A sample of 42 subjects will be divide into three subgroup: healthy control, PD with MCI (PD-MCI) and PD without MCI (PD-ctrl). Those subjects will undergo a specific neuropsychological evaluation and, to measure the electro-cortical activity, high-density electroencephalography (hdEEG) will be record during both resting state and cognitive tasks. Furthermore, hdEEG data will be combine with structural magnetic resonance to obtain information about network connectivity.

NCT Number	NCT06640673
Lead Sponsor	IRCCS San Camillo, Venezia, Italy
Conditions	Parkinson Disease, Parkinson Disease, Mild Cognitive Impairment, Healthy
Enrollment	42 participants
Start Date	2023-06-18
Primary Completion	2024-12-01 (estimated)
Study Completion	2025-05 (estimated)
Updated on ClinicalTrials.gov	2024-10-15