Intraosseous (IO) Cefazolin and Vancomycin in Primary Total Knee Arthroplasty (TKA)

The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does IO administration of vancomycin and cefazolin protect against perioperative exposure risks? Is there a difference in post-operative complication rates between IV and IO administration of these drugs? Participants will be randomized to receive either the standard of care IV administration of Vancomycin and Cefazolin, or the IO administration of Vancomycin and Cefazolin.

NCT Number	NCT06640491
Lead Sponsor	The Methodist Hospital Research Institute
Conditions	Total Knee Arthroplasty
Enrollment	40 participants
Start Date	2025-05-15
Primary Completion	2030-12-01 (estimated)
Study Completion	2035-12-01 (estimated)
Updated on ClinicalTrials.gov	2025-05-18