Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.

NCT Number	NCT06605417
Lead Sponsor	Fundacion Clinic per a la Recerca Biomédica Collaborators: Institut National de la Santé Et de la Recherche Médicale, France, University Hospital Tuebingen, University of Florence, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, University Of Perugia, German Cancer Research Center, Karolinska Institutet, Maria Sklodowska-Curie National Research Institute of Oncology, Institut Curie, Medical University of Gdansk, Princess Maxima Center for Pediatric Oncology, Institut Català d'Oncologia
Conditions	Congenital Melanocytic Nevi, Melanoma, Skin, Nevi and Melanomas
Enrollment	100 participants
Start Date	2024-01-01
Primary Completion	2026-03-31 (estimated)
Study Completion	2026-11-30 (estimated)
Updated on ClinicalTrials.gov	2025-02-27