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Understanding the Transition from Normal Melanocytes to Nevus to Melanoma

Study acronym: NevustoMel
StatusRecruiting
PhaseNot specified
Started
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Record status
This record was last updated February 27, 2025 (before its estimated March 31, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Eligibility criteria shortened, about 61 wordsv2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The primary objective of this study is to identify the molecular identity profiles of all cellular states that characterize the progression from benign nevi to malignant melanoma in CAYA patients with L/GCMN. The secondary objectives are: * To longitudinally characterize the cell-free DNA (cfDNA) from CAYA patients. * To improve the early diagnosis and treatments for intermediate conditions such as L/GCMN through evidence-based interpretation of personal risk from endogenous or exogenous sources. * To test pre-clinical strategies to best model and improve patient response.
Trial Details
NCT Number NCT06605417
Lead Sponsor Fundacion Clinic per a la Recerca Biomédica
Collaborators: Institut National de la Santé Et de la Recherche Médicale, France, University Hospital Tuebingen, University of Florence, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, University Of Perugia, German Cancer Research Center, Karolinska Institutet, Maria Sklodowska-Curie National Research Institute of Oncology, Institut Curie, Medical University of Gdansk, Princess Maxima Center for Pediatric Oncology, Institut Català d'Oncologia
Conditions
(from sponsor)		 Congenital Melanocytic Nevi, Melanoma, Skin, Nevi and Melanomas
Related terms Melanoma, Nevi and Melanomas
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov