Genetics and Environment iNtersection In the ALS-FTD Spectrum: an Italian Twins Cohort studY With a Multi-Omics Approach

The goal of this study is to learn from discordant twins affected by Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia the contribution of genetic background versus environmental exposure. The main questions it aims to answer is: * How far does the genetic background explain the onset of ALS/FTD in discordant twins? * Which environmental factors and events occurring in post-fetal life influence the onset or progression of this neurodegenerative condition? Participants with ALS and/or FTD with a monozygotic or dizygotic twin willing to contribute to this research will be followed up for two years by specialized Motor Neuron Disorders centers in Italy, donating biological specimen for -omic sciences analysis, and checking out if prodromal signs/symptoms of these two conditions will develop during time.

NCT Number	NCT06595212
Lead Sponsor	Azienda Ospedaliero-Universitaria di Modena Collaborators: A.O.U. Città della Salute e della Scienza - Molinette Hospital, Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Careggi
Conditions	ALS, FTD
Enrollment	45 participants
Start Date	2024-01-29
Primary Completion	2026-01-29 (estimated)
Study Completion	2026-01-30 (estimated)
Updated on ClinicalTrials.gov	2025-02-04