Clinical Trial

Node-Sparing Short-Course Radiation With CAPOX and Sintilimab for MSS Locally Advanced Colon Cancer: A Randomized, Prospective, Multicenter Study

Study acronym: mRCAT-C
Not Yet Recruiting Phase 2
View on ClinicalTrials.gov →
Record status
This record was last updated September 19, 2024 (before its estimated September 30, 2025 completion). Its status may not reflect the trial's current state.
Summary
This study aims to evaluate the use of node-sparing short-course radiotherapy combined with chemotherapy and Sintilimab, or chemotherapy alone, as neoadjuvant therapy for MSS-type locally advanced colon cancer. The goal is to explore the efficacy and safety of combining node-sparing short-course radiotherapy with chemotherapy and immunotherapy in the neoadjuvant setting for MSS-type locally advanced colon cancer, while also investigating the specific role of regional lymph nodes in tumor immunotherapy.
Trial Details
NCT Number NCT06594692
Lead Sponsor Sir Run Run Shaw Hospital
Conditions Microsatellite Stable (MSS) Colon Cancer, Locally Advanced Colon Cancer
Enrollment 140 participants
Start Date 2024-10
Primary Completion 2025-09-30 (estimated)
Study Completion 2026-09-30 (estimated)
Updated on ClinicalTrials.gov 2024-09-19