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B2AD-Risk AFDAS Evolution of Burden of AF

Study acronym: B2AD-Risk AF
StatusRecruiting
PhaseNot applicable
Started2025-10-16
View on ClinicalTrials.gov ↗

Amendment history

2026-05-03
notable
Not Yet Recruiting→Recruiting Study Status, Sponsor/Collaborators, Oversight, Study Design, Arms and Interventions, Contacts/Locations, IPDSharing v2
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2026-10→2027-10
Completion date2026-10→2027-10
Start dateestimated 2025-05→confirmed 2025-10-16
Study arms3→1
Lead sponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's→Luciano A. Sposato
Study sites1 entry, revised
Heart &and Brain Lab, Western University
2025-03-27
minor
Study Status, Study Description, Arms and Interventions, Contacts/Locations, IPDSharing v1
Primary completion date2025-10→2026-10
Start date2024-10→2025-05
Study description+75 characters
[...] progresses over time in patients with AFDAS. Specifically, wethe investigators aim to track changes in the severity and frequency of AF ep [...] heart activity for 7 to 30 days (7-30-day Holter monitor). WeThe investigators hypothesize that the burden of AF (severity and frequency o [...] dually worsens, increasing their risk of stroke. Therefore, wethe investigators will evaluate the progression of AF burden over time. Throughout the study, wethe investigators will regularly measure AF burden (frequency and severity of [...] ticipants will be followed up to 24 months. To gather data, wethe investigators will us [...]
Study sitescontacts updated at 1 of 1 site
2024-09-06
minor
Original filing
3,268 trials monitored
See 122 trials at risk
Each year, 7.8 million people worldwide experience an ischemic stroke, often caused by atrial fibrillation (AF). AF is a major contributor to severe, disabling, and deadly strokes. About 20% to 30% of ischemic stroke patients have AF before their stroke. Of the remaining 70% to 80% without known arrhythmias, up to 24% are newly diagnosed with AF after intensive cardiac monitoring, totaling 1.3 to 1.5 million new AF cases detected after stroke globally each year. Oral anticoagulants (OACs) can reduce stroke risk related to AF by 64% and lead to milder strokes with lower disability and mortality. Neurologists use cardiac monitoring to detect AF in stroke patients. This study focuses on patients who have had an ischemic stroke and are newly diagnosed with AF. The goal is to understand how AF progresses over time. The investigators will track changes in AF severity and frequency, monitor biomarkers related to heart health, assess the size and function of the left atrium, and observe new risk factors like hypertension. Patients will be grouped based on their AF diagnosis method: ECG, a portable device recording heart activity for less than 7 days, or one recording for 7 to 30 days. The investigators hypothesize that AF burden will increase, new risk factors will emerge, biomarkers will rise, and the left atrium will worsen over time. Participants will be followed for up to 24 months with regular assessments. The study aims to provide insights into AF progression in stroke patients, potentially improving treatments and prevention strategies.
Trial Details
NCT Number NCT06589700
Lead Sponsor Luciano A. Sposato
Conditions Stroke, Atrial Fibrillation
Enrollment 24 participants
Start Date 2025-10-16
Primary Completion 2027-10 (estimated)
Study Completion 2027-10 (estimated)
Updated on ClinicalTrials.gov 2026-05-07