Interferon Pathway Activation in Monogenic and Nonmonogenic Forms of Pediatric SLE

Pediatric SLE includes monogenic forms, some of which involve the interferon type I (IFN-I) pathway. The IFN-I pathway is renally active in adult SLE and correlates with the extent of renal damage. In pediatric SLE, and particularly in lupus nephritis, activation of the IFN-I pathway has never been studied, nor is it known whether monogenic forms underlie more pronounced interferon activation.

NCT Number	NCT06586710
Lead Sponsor	Meyer Children's Hospital IRCCS
Conditions	Systemic Lupus Erythematosus of Childhood
Enrollment	60 participants
Start Date	2023-06-07
Primary Completion	2025-06-30 (estimated)
Study Completion	2025-12-31 (estimated)
Updated on ClinicalTrials.gov	2024-09-19