Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease

The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease. Participants will be randomly allocated to one of two groups either performing cardiovascular training (experimental group) or stretching (control group) for twelve weeks, three times a week. The primary aim is to examine whether moderate-intense cardiovascular training (MICT) improves procedural memory formation (primary outcome) compared to stretching. Secondary outcomes include episodic memory formation, cognitive function, cardiorespiratory fitness, sleep quality, and brain-derived neurotrophic factor (BDNF) blood concentration levels.

NCT Number	NCT06580977
Lead Sponsor	Heidelberg University Collaborators: German Foundation for Neurology, University Hospital Heidelberg, Universitätsmedizin Mannheim, SRH Kurpfalzkrankenhaus Heidelberg
Conditions	Parkinson Disease
Enrollment	60 participants
Start Date	2024-02-27
Primary Completion	2026-12 (estimated)
Study Completion	2027-07 (estimated)
Updated on ClinicalTrials.gov	2024-08-30