WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise

The goal of this study is to define how treatment of obesity impacts cardiometabolic performance during exercise in patients with established HFpEF or at risk for HFpEF. Multi-dimensional physical activity, including 6 minute walk distance, resting metabolic rate, the metabolic cost of initiating exercise, and low-level, intermediate, peak exercise, and recovery oxygen utilization patterns will be examined in relation to weight loss in people having bariatric surgery. The investigators also aim to learn more about the relationship between obesity, exercise intolerance, and heart failure with preserved ejection fraction (HFpEF). The investigators are interested in the extent to which HFpEF\'s manifestations are preventable or reversible with weight-loss interventions. The main questions it aims to answer are: 1. How does weight loss surgery affect comprehensive measures of physical activity? 2. What are the biochemical signatures of obesity and their reversibility in patients with HFpEF and obesity?

NCT Number	NCT06576050
Lead Sponsor	Massachusetts General Hospital Collaborators: Amgen
Conditions	Heart Failure, Obesity, Weight Loss, Heart Failure With Preserved Ejection Fraction
Enrollment	21 participants
Start Date	2022-01-25
Primary Completion	2024-08-02 (estimated)
Study Completion	2025-08-02 (estimated)
Updated on ClinicalTrials.gov	2026-08-13