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Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis

StatusRecruiting
PhasePhase 2
Started2025-11-03
View on ClinicalTrials.gov ↗

Amendment history

2025-11-06
minor
Study Status, Contacts/Locations v3
Re-verified, no change to tracked fields
2025-11-03
notable
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2025-11-15→confirmed 2025-11-03
Study sitesdetails revised at 1 of 1 site
2025-10-22
minor
Study Status, Eligibility, Contacts/Locations v1
Primary completion date2026-03→2027-01
Completion date2026-06→2027-01
Start date2025-01→2025-11-15
Eligibility criteria+58 characters
[...] pulmonologist Willingness to participate in home phlebotomy orand to travel to a local Quest Diagnostics laboratory Reside in one of the following states: California, Arizona, Georgia, Louisiana, Minnesota, Oregon Exclusion Criteria: FVC &amp;lt;< 40% of predicted, DLCO &amp;lt;< 30% of predicted, FEV1/FVC with Z-score &amp;lt;< -1.645 or confidence interval &amp;lt; <1.0 within 3 months of screening. If Z-scores or confidence intervals are not available, then FEV1/FVC &amp;lt;< the lower limit of normal will be used as exclusion Evidenc [...] /symptoms of connective tissue disease, including ANA tit [...]
2024-08-20
minor
Original filing
The goal of this clinical trial is to learn if a clinical trial for idiopathic pulmonary fibrosis (IPF) can recruit and retain participants from their home to study whether a combination of zinc and nicotinamide riboside can treat iIPF. The main questions are: Can the investigators recruit participants, and can participants complete study procedures without physically coming into specific clinical trial sites? Can people with IPF experience improvement in symptoms, quality of life, or functioning if they are take these supplements? The investigators will compare zinc and nicotinamide riboside to matched placebos (look-alike substances that contain no drug) to see if these supplements treat symptoms or lung function in people with IPF. Participants will: Take drug these supplements twice a day for 24 weeks. Complete pulmonary function testing and six minute walk tests with their own pulmonologists every 12 weeks. Complete a high resolution CT scan at the start and end of the study. Complete video study visits with the research team every 4 weeks. Complete surveys about their symptoms and the number of times they take the medication.
Trial Details
NCT Number NCT06567717
Lead Sponsor Cedars-Sinai Medical Center
Conditions Idiopathic Pulmonary Fibrosis
Enrollment 60 participants
Start Date 2025-11-03
Primary Completion 2027-01 (estimated)
Study Completion 2027-01 (estimated)
Updated on ClinicalTrials.gov 2025-11-10