Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma

Multicentric prospective model-based de-escalation of the elective clinical target volumes (CTV) in radiotherapy of oropharyngeal carcinoma of all stages with the goal to reduce toxicity. The study investigates the feasibility of this approach as measured by the number of expected out-of-field recurrencies based on the individual patient's state of disease progression and risk factors

NCT Number	NCT06563362
Lead Sponsor	University of Zurich Collaborators: Insel Gruppe AG, University Hospital Bern, University Hospital, Geneva, Ospedale Regionale Bellinzona e Valli, Réseau Hospitalier Neuchâtelois, Kantonsspital Aarau
Conditions	Oropharynx Cancer
Enrollment	120 participants
Start Date	2025-02-04
Primary Completion	2029-02-28 (estimated)
Study Completion	2030-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-06-01